| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Chromosome 17 abnormalities and mutation of the TP53 gene: correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia
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| Autores: |
Otero,Luize
Cavalcanti Júnior,Geraldo Barroso
Klumb,Claudete Esteves
Scheiner,Marcos Antonio Mauricio
Magluta,Eliane Pereira Simões
Fernandez,Teresa de Souza
Silva,Maria Luiza Macedo
Pires,Virgínia
Andrade,Gabriela Vasconcelos
Maia,Raquel Ciuvalschi
Tabak,Daniel
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| Data: |
2005-03-01
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| Ano: |
2005
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| Palavras-chave: |
Chronic myeloid leukemia
Chromosome 17
TP53 gene
P53 protein
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| Resumo: |
chronic myeloid leukemia (CML) have been described. This chromosomal region contains the tumor suppressor gene TP53 that may be an important factor in the evolution of this disease. In this study, we used flow cytometry and western blotting to assess p53 protein expression and single stranded conformational polymorphism to examine TP53 gene alterations in three patients with CML who showed alterations in 17p. Only the case with del(17)(p11) had p53 expression positive by flow cytometry and an abnormal migration pattern by SSCP analysis. The importance of the correlation between the results obtained with these techniques, as well as the clinical course of the patients, are discussed.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100007
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572005000100007
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.28 n.1 2005
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| Direitos: |
info:eu-repo/semantics/openAccess
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